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Article

Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments.

Cell reports - 2 Mar 2021

Liu Hualan, Shiver Anthony L, Price Morgan N, Carlson Hans K, Trotter Valentine V, Chen Yan, Escalante Veronica, Ray Jayashree, Hern Kelsey E, Petzold Christopher J, Turnbaugh Peter J, Huang Kerwyn Casey, Arkin Adam P, Deutschbauer Adam M

Abstract excerpt

Harnessing the microbiota for beneficial outcomes is limited by our poor understanding of the constituent bacteria, as the functions of most of their genes are unknown. Here, we measure the growth of a barcoded transposon mutant library of the gut commensal Bacteroides thetaiotaomicron on 48 carbon sources, in the presence of 56 stress-inducing compounds, and during mono-colonization of gnotobiotic mice. We...

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Identifiers

PMID: 33657378
DOI: 10.1016/j.celrep.2021.108789
PMCID: PMC8121099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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