Article

Phosphorothioate DNA modification by BREX Type 4 systems in the human gut microbiome

2024-06-03

Abstract excerpt

Among dozens of microbial DNA modifications regulating gene expression and host defense, phosphorothioation (PT) is the only known backbone modification, with sulfur inserted at a non-bridging oxygen by dnd and ssp gene families. Here we explored the distribution of PT genes in 13,663 human gut microbiome genomes, finding that 6.3% possessed dnd or ssp genes predominantly in Bacillota, Bacteroidota, and Pseudo...

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Literature Corpus work: bfe2485a-1411-5141-bdf8-ed81ec83ff0f
DOI: 10.1101/2024.06.03.597175

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