Article
Ecology and molecular targets of hypermutation in the global microbiome.
Nature communications - 24 May 2021
Roux Simon, Paul Blair G, Bagby Sarah C, Nayfach Stephen, Allen Michelle A, Attwood Graeme, Cavicchioli Ricardo, Chistoserdova Ludmila, Gruninger Robert J, Hallam Steven J, Hernandez Maria E, Hess Matthias, Liu Wen-Tso, McAllister Tim A, O'Malley Michelle A, Peng Xuefeng, Rich Virginia I, Saleska Scott R, Eloe-Fadrosh Emiley A
Abstract excerpt
Changes in the sequence of an organism's genome, i.e., mutations, are the raw material of evolution. The frequency and location of mutations can be constrained by specific molecular mechanisms, such as diversity-generating retroelements (DGRs). DGRs have been characterized from cultivated bacteria and bacteriophages, and perform error-prone reverse transcription leading to mutations being introduced in specific...
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