Article

Peripheral inflammation mediates midbrain Lrrk2 kinase activity via Rab32 expression

2025-09-06

Abstract excerpt

<h4>ABSTRACT</h4> Mutations that increase leucine-rich repeat kinase 2 (LRRK2) activity confer significant risk for Parkinson’s disease (PD), yet incomplete disease penetrance suggest additional factors are required to manifest disease. We recently identified RAB32 Ser71Arg as a Mendelian gene for PD. Here, we establish Rab32 as a key mediator linking peripheral inflammation to Lrrk2 activation. We show that Rab3...

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Literature Corpus work: ee818775-5339-58c9-9ddb-6e4f95709b9f
DOI: 10.1101/2025.09.05.674552

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