The mechanisms of ion chanels involved in developmental neurotoxicity due to anesthetic exposure

Abstract excerpt

General anesthesia is an important clinical treatment drug.General anesthesia is the result of the mixed interaction between a variety of nonspecific drugs and multiple targets in the nervous system. Preclinical studies have shown that cognitive impairment and behavioral abnormalities in rodents persist into adulthood after exposure to anesthesia, revealing the potential neurotoxicity of anaesthetic drugs.Studies...

Topics

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• Animals, Genetically Modified
• Central Nervous System
• Dose-Response Relationship, Drug
• Gene Targeting
• Ion Channel Gating
• Ion Channels
• Mice
• Mutation

Identifiers and source

Literature Corpus work

10fa31bc-b03f-51c6-ab1c-babeac4e4fb1

DOI

10.21203/rs.3.rs-1608420/v1