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Article

The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns.

Best practice & research. Clinical anaesthesiology - 1 Sept 2010

Istaphanous George K, Ward Christopher G, Loepke Andreas W

Abstract excerpt

Mounting evidence from animal studies has implicated that all commonly used anaesthetics and sedatives may induce widespread neuronal cell death and result in long-term neurological abnormalities. These findings have led to serious questions regarding the safe use of these drugs in young children. In humans, recent findings from retrospective, epidemiological studies do not exclude the possibility of an...

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Identifiers

PMID: 21033018
DOI: 10.1016/j.bpa.2010.02.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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