Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitory ligand-gated ion channels as substrates for general anesthetic actions.

Handbook of experimental pharmacology - 1 Jan 2008

Zeller A, Jurd R, Lambert S, Arras M, Drexler B, Grashoff C, Antkowiak B, Rudolph U

Abstract excerpt

General anesthetics have been in clinical use for more than 160 years. Nevertheless, their mechanism of action is still only poorly understood. In this review, we describe studies suggesting that inhibitory ligand-gated ion channels are potential targets for general anesthetics in vitro and describe how the involvement of y-aminobutyric acid (GABA)(A) receptor subtypes in anesthetic actions could be demonstrated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Ion Channels

Share to Mice, Transgenic

Share to Receptors, GABA-A

Share to Receptors, Glycine

Source

Identifiers

PMID: 18175085
DOI: 10.1007/978-3-540-74806-9_2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibitory ligand-gated ion channels as substrates for general anesthetic actions.PMID 18175085Read ↗

The GABAA receptor family: molecular and functional diversity.Semantic proximity Read ↗

Inhibition of Ligand-Gated TRPA1 by General Anesthetics.Semantic proximity Read ↗

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes.Semantic proximity Read ↗

From ion currents to genomic analysis: recent advances in GABAA receptor research.Semantic proximity Read ↗

Functional β1-selectivity of novel pyrazoloquinolinones at GABAA receptors revealed by electrophysiology, mutagenesis and docking.Semantic proximity Read ↗

Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.Semantic proximity Read ↗

Differentiating the role of gamma-aminobutyric acid type A (GABAA) receptor subtypes.Semantic proximity Read ↗

A Single phenylalanine residue in the main intracellular loop of α1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol.Semantic proximity Read ↗

Therapeutically leveraging GABA A receptors in cancerSemantic proximity Read ↗

Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists.Semantic proximity Read ↗

Enhancement of α5-containing γ-aminobutyric acid type A receptors by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6) is abolished by the β3(N265M) mutation.Semantic proximity Read ↗

The mechanisms of ion chanels involved in developmental neurotoxicity due to anesthetic exposureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.