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Gentisic acid inhibits renal fibrosis by reprogramming glycolytic metabolism and regulating H3K18la

2025-08-14

Abstract excerpt

<h4>Background: </h4> Renal fibrosis, a hallmark of chronic kidney disease, is characterized by enhanced glycolysis and lactate accumulation. As a precursor of histone lactylation modification, lactate may be involved in the progression of renal fibrosis. Our previous studies found that gentisic acid (GA) can alleviate renal fibrosis, but its specific mechanism of action remains unclear. <h4>Purpose: </h4> This s...

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Literature Corpus work
e16acf5f-1b40-582f-84db-884b213c5546
DOI
10.22541/au.175517326.63070058/v1
Open publication

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