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SGLT2 inhibitor empagliflozin ameliorates tubulointerstitial fibrosis in DKD by downregulating renal tubular PKM2

2025-04-02

Abstract excerpt

<title>Abstract</title> <p>Background and Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to prevent the progression of diabetic kidney disease (DKD). However, their impact on renal fibrosis remains largely uninvestigated. This study aimed to explore the effect of SGLT2 inhibitor empagliflozin on renal fibrosis in DKD patients and DKD models, and the molecular mechanisms involved. Met...

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Literature Corpus work
6508adf2-affa-5eb0-891b-78f6d5563935
DOI
10.21203/rs.3.rs-5563608/v1
Open publication

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SGLT2 inhibitor empagliflozin ameliorates tubulointerstitial fibrosis in DKD by downregulating renal tubular PKM2DOI 10.21203/rs.3.rs-5563608/v1
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