Back to search

Article

Microbes suppress genetic disorders of hyper-activated Ras by inhibiting iron-mediated growth factor modulation in <i>C. elegans</i>

2025-10-01

Abstract excerpt

Gut bacteria play crucial roles in promoting host health, but their ability to suppress the effects of genetic defects remains unclear. Ras(gain-of-function, gf) mutations are involved in various developmental disorders, thus identifying bacterial-activity changes capable of repressing the effects of hyper-activated Ras is important. Here, we screened mutations of all non-essential E. coli genes and identified 1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
10b3780a-c59a-5a82-8b55-7a824f9c2894
DOI
10.1101/2025.09.30.679430
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Microbes suppress genetic disorders of hyper-activated Ras by inhibiting iron-mediated growth factor modulation in <i>C. elegans</i>DOI 10.1101/2025.09.30.679430
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways.Semantic proximity
Bacterial purine metabolism modulates <i>C. elegans</i> development and stress tolerance via DAF-16 translocationSemantic proximity
Enterobactin carries iron into <i>C. elegans</i> and mammalian intestinal cells by a mechanism independent of divalent metal transporter DMT1Semantic proximity
Longevity-promoting human gut <i>Bifidobacteria</i> strains require distinct cytoprotective pathways and share dependence on host lipid regulationSemantic proximity
Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in miceSemantic proximity
Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF-16.Semantic proximity
Biochemistry, function, and deficiency of vitamin B <sub>12</sub> in <i>Caenorhabditis elegans</i>Semantic proximity
Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.Semantic proximity
Proximate Causes of Ageing Are Likely Evolutionarily Bound and Appropriate Countermeasure Design Requires New Approaches<strong> </strong>Semantic proximity
Gut Microbial Genetic Variation Regulates Host Reproduction.Semantic proximity
Discovery of nonautonomous modulators of activated Ras.Semantic proximity
Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegansSemantic proximity
Select a neighboring publication to make it the new centre.