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Article

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.

BMC biology - 31 Jul 2012

Virk Bhupinder, Correia Gonçalo, Dixon David P, Feyst Inna, Jia Jie, Oberleitner Nikolin, Briggs Zoe, Hodge Emily, Edwards Robert, Ward John, Gems David, Weinkove David

Abstract excerpt

BACKGROUND: Gut microbes influence animal health and thus, are potential targets for interventions that slow aging. Live E. coli provides the nematode worm Caenorhabditis elegans with vital micronutrients, such as folates that cannot be synthesized by animals. However, the microbe also limits C. elegans lifespan. Understanding these interactions may shed light on how intestinal microbes influence mammalian aging....

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Identifiers

PMID: 22849329
DOI: 10.1186/1741-7007-10-67
PMCID: PMC3583181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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