Back to search

Article

Longevity-promoting human gut <i>Bifidobacteria</i> strains require distinct cytoprotective pathways and share dependence on host lipid regulation

2025-10-17

Abstract excerpt

Human gut Bifidobacteria are abundant during infancy and have been reported to be enriched in some exceptionally long-lived populations, yet whether their beneficial effects on lifespan and healthspan are broadly shared across the genus or restricted to specific strains remains unclear. Using an anaerobic bacteria– Caenorhabditis elegans platform with heat-killed diets, we systematically compared 11 human gut B...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
91163dc7-eb96-52a7-883b-7558bf38df93
DOI
10.1101/2025.10.17.682934
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Longevity-promoting human gut <i>Bifidobacteria</i> strains require distinct cytoprotective pathways and share dependence on host lipid regulationDOI 10.1101/2025.10.17.682934
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways.Semantic proximity
A microbiota-derived metabolite, 3-phenyllactic acid, prolongs healthspan by enhancing mitochondrial function and stress resilience via SKN-1/ATFS-1 in C. elegansSemantic proximity
Mechanism underlying prolongevity induced by bifidobacteria in Caenorhabditis elegans.Semantic proximity
Branched chain fatty acid-rich diet promotes lipid droplet enlargement and impacts organismal health in Caenorhabditis elegansSemantic proximity
A diet of oxidative stress-adapted bacteria improves stress resistance and lifespan in <i>C. elegans</i> via p38-MAPKSemantic proximity
Killed Bifidobacterium longum enhanced stress tolerance and prolonged life span of Caenorhabditis elegans via DAF-16Semantic proximity
Commensals, probiotics and pathogens in the C aenorhabditis elegans modelSemantic proximity
3-phenyllactic acid promotes healthspan through SKN-1/ATFS-1-mediated mitochondrial activation and stress resilienceSemantic proximity
Anti-Inflammatory Lactobacillus rhamnosus CNCM I-3690 Strain Protects against Oxidative Stress and Increases Lifespan in Caenorhabditis elegansSemantic proximity
Heat-killed probiotic <i>Levilactobacillus brevis</i> MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in <i>Caenorhabditis elegans</i>Semantic proximity
C. elegans and its bacterial diet as a model for systems-level understanding of host-microbiota interactions.Semantic proximity
Lacticaseibacillus rhamnosus HA-114 and Bacillus subtilis R0179 Prolong Lifespan and Mitigate Amyloid-β Toxicity in C. elegans via Distinct MechanismsSemantic proximity
Select a neighboring publication to make it the new centre.