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Article

Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways.

The EMBO journal - 1 Dec 2025

Das Priyanka, Ravi, Singh Jogender

Abstract excerpt

Gut microbes play a crucial role in modulating host lifespan. However, the microbial factors that influence host longevity and their mechanisms of action remain poorly understood. Using the expression of Caenorhabditis elegans FAT-7, a stearoyl-CoA 9-desaturase, as a proxy for lifespan modulation, we conduct a genome-wide bacterial mutant screen and identify 26 Escherichia coli mutants that enhance host lifespan....

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Identifiers

PMID: 41214214
DOI: 10.1038/s44318-025-00634-7
PMCID: PMC12706066

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