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Article

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody.

Alzheimer's research & therapy - 24 May 2018

Syvänen Stina, Hultqvist Greta, Gustavsson Tobias, Gumucio Astrid, Laudon Hanna, Söderberg Linda, Ingelsson Martin, Lannfelt Lars, Sehlin Dag

Abstract excerpt

BACKGROUND: Amyloid-β (Aβ) immunotherapy is one of the most promising disease-modifying strategies for Alzheimer's disease (AD). Despite recent progress targeting aggregated forms of Aβ, low antibody brain penetrance remains a challenge. In the present study, we used transferrin receptor (TfR)-mediated transcytosis to facilitate brain uptake of our previously developed Aβ protofibril-selective mAb158, with the...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29793530
DOI: 10.1186/s13195-018-0377-8
PMCID: PMC5968497

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