Article

Induction of anergy in human T lymphocytes by exposure to single amino acid mutated antigens

2025-04-20

Abstract excerpt

Anergy is a condition of immune T cells becoming sustainably inactive. Theoretically, it occurs when a T cell recognizes its antigen but cannot be active. If we could artificially induce anergy to a specific T cell clone, this should provide a therapeutic strategy for autoimmune disease. One possible method to induce anergy is to expose a T cell to an unstably presented antigen, which makes the T cell bind to the...

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Literature Corpus work: 109c6750-556d-57da-bca8-369df7fceac6
DOI: 10.1101/2025.04.15.649051

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