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Article

The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2004

Seroogy Christine M, Soares Luis, Ranheim Erik A, Su Leon, Holness Claire, Bloom Debra, Fathman C Garrison

Abstract excerpt

Acquisition of the anergy phenotype in T cells is blocked by inhibitors of protein synthesis and calcineurin activity, suggesting that anergic T cells may have a unique genetic program. Retroviral transduction of hemopoietic stem cells from TCR transgenic mice and subsequent reconstitution of syngeneic mice to express the E3 ubiquitin ligase, gene related to anergy in lymphocytes (GRAIL), or an enzymatically...

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PMID: 15210761
DOI: 10.4049/jimmunol.173.1.79

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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