Article
T-cell anergy: from phenotype to genotype and back.
Immunologic research - 1 Jan 2003
Seroogy Christine M, Fathman C Garrison
Abstract excerpt
For many decades, anergy has been used as a descriptive term to describe a state of antigen-specific unresponsiveness. A better understanding of this phenotype was revealed in the 1980s using in vitro model systems. These model systems demonstrated that protein synthesis and mobilization of Ca2+ was required leading to the pursuit of a novel gene(s) that would be unique to the anergy phenotype. Several putative...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Cell Cycle
- Clonal Anergy
- Genotype
- Mice
- Phenotype
- Signal Transduction