Induction and stability of the anergic phenotype in T cells.

doi:10.1016/j.smim.2013.10.010

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Article

Induction and stability of the anergic phenotype in T cells.

Seminars in immunology - 15 Nov 2013

Valdor Rut, Macian Fernando

Abstract excerpt

One of the mechanisms that are in place to control the activation of mature T cells that bear self-reactive antigen receptors is anergy, a long-term state of hyporesponsiveness that is established in T cells in response to suboptimal stimulation. T cells receive signals that result not only from antigen recognition and costimulation but also from other sources, including cytokine receptors, inhibitory receptors...

Topics

Animals
Clonal Anergy
Gene Expression Regulation
Humans
Lymphocyte Activation
Phenotype
Signal Transduction
T-Lymphocyte Subsets
Transcription, Genetic

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Identifiers

PMID: 24211041
DOI: 10.1016/j.smim.2013.10.010
PMCID: PMC3927995

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