Article
Induction and stability of the anergic phenotype in T cells.
Seminars in immunology - 15 Nov 2013
Valdor Rut, Macian Fernando
Abstract excerpt
One of the mechanisms that are in place to control the activation of mature T cells that bear self-reactive antigen receptors is anergy, a long-term state of hyporesponsiveness that is established in T cells in response to suboptimal stimulation. T cells receive signals that result not only from antigen recognition and costimulation but also from other sources, including cytokine receptors, inhibitory receptors...
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