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Article

A new T-cell activation mode for suboptimal doses of antigen under the full activation of T cells with different specificity.

European journal of immunology - 1 Jun 2015

Shibuya Mihoko, Fujio Keishi, Shoda Hirofumi, Okamura Tomohisa, Okamoto Akiko, Sumitomo Shuji, Yamamoto Kazuhiko

Abstract excerpt

Loss of tolerance for autoantigens is a common feature in autoimmune diseases. Bystander T-cell activation is the activation of T cells to produce functional changes through TCR-independent stimulation. Although bystander activation may be related to tolerance loss to multiple autoantigens, the activation mechanism of T cells directed to an autoantigen with limited amount is not clear. We investigated an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25789709
DOI: 10.1002/eji.201444965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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