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Article

Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages.

Nature communications - 24 Aug 2016

Doobin David J, Kemal Shahrnaz, Dantas Tiago J, Vallee Richard B

Abstract excerpt

Microcephaly is a cortical malformation disorder characterized by an abnormally small brain. Recent studies have revealed severe cases of microcephaly resulting from human mutations in the NDE1 gene, which is involved in the regulation of cytoplasmic dynein. Here using in utero electroporation of NDE1 short hairpin RNA (shRNA) in embryonic rat brains, we observe cell cycle arrest of proliferating neural...

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Identifiers

PMID: 27553190
DOI: 10.1038/ncomms12551
PMCID: PMC4999518

Genes

NDE1
NDEL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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