Article

Single-cell transcriptome of retinal myeloid cells in response to transplantation of human neurons reveals reversibility of microglial activation

2025-05-21

Abstract excerpt

<h4>ABSTRACT</h4> The host retinal microglia and macrophage activation remains a major challenge for the integration of donor neurons following transplantation. Previously, we and others have shown that it is possible to increase donor retinal ganglion cell (RGC) survival by inhibiting the microglia-RGC interaction with Annexin V or through reprogramming microglia with the soluble Fas ligand. However, the exact m...

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Literature Corpus work: 108b3557-91e0-5f73-8deb-d126376f244f
DOI: 10.1101/2025.05.16.654622

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