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Single-cell RNA sequencing reveals roles of unique retinal microglia types in early diabetic retinopathy

26 Feb 2024

Abstract excerpt

BACKGROUND: The pathophysiological mechanisms of diabetic retinopathy (DR), a blinding disease, are intricate. DR was thought to be a microvascular disease previously. However, growing studies have indicated that the retinal microglia-induced inflammation precedes microangiopathy. The binary concept of microglial M1/M2 polarization paradigms during inflammatory activation has been debated. In this study, we...

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PMID: 38409074
DOI: 10.1186/s13098-024-01282-3

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