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Article

Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.

The Journal of biological chemistry - 1 Jan 2000

Malcolm Tess R, Belousoff Matthew J, Venugopal Hariprasad, Borg Natalie A, Drinkwater Nyssa, Atkinson Sarah C, McGowan Sheena

Abstract excerpt

M17 leucyl aminopeptidases are metal-dependent exopeptidases that rely on oligomerization to diversify their functional roles. The M17 aminopeptidases from Plasmodium falciparum (PfA-M17) and Plasmodium vivax (Pv-M17) function as catalytically active hexamers to generate free amino acids from human hemoglobin and are drug targets for the design of novel antimalarial agents. However, the molecular basis for...

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Identifiers

PMID: 33303633
DOI: 10.1074/jbc.RA120.016313
PMCID: PMC7948507

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