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Article

Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum.

Journal of molecular biology - 13 Dec 2002

Kim Jeong Sun, Groll Michael, Musiol Hans Jürgen, Behrendt Raymond, Kaiser Markus, Moroder Luis, Huber Robert, Brandstetter Hans

Abstract excerpt

The proposed pathway and mechanism of substrate entry and product egress in the hexameric D3 symmetric tricorn protease from Thermoplasma acidophilum were explored by crystallographic studies of ligand complexes and by structure-based mutagenesis. Obstruction of the pore within the 7-bladed beta-...

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PMID: 12470958
DOI: 10.1016/s0022-2836(02)01153-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12470958-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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