Article
A mechanistic mathematical model of initiation and malignant transformation in sporadic vestibular schwannoma
2021-10-04
Abstract excerpt
A vestibular schwannoma (VS) is a relatively rare, benign tumour of the eighth cranial nerve, often involving alterations to the gene NF2 . Previous mathematical models of schwannoma incidence have not attempted to account for alterations in specific genes, and could not distinguish between point mutations and loss of heterozygosity (LOH). Here, we present a mechanistic approach to modelling initiation and malign...
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Identifiers and source
- Literature Corpus work
- 1075bffa-25cc-50da-84b7-2e549bca2959
- DOI
- 10.1101/2021.10.03.457528