The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level.

doi:10.1097/01.mao.0000180484.24242.54

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Article

The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology - 1 Feb 2006

Neff Brian A, Welling D Bradley, Akhmametyeva Elena, Chang Long-Sheng

Abstract excerpt

OBJECTIVE: The goal of this article was to review concisely what is currently known about the tumorigenesis of vestibular schwannomas. BACKGROUND: Recent advances in molecular biology have led to a better understanding of the cause of vestibular schwannomas. Mutations in the neurofibromatosis type 2 tumor suppressor gene (NF2) have been identified in these tumors. In addition, the interactions of merlin, the...

Topics

Alternative Splicing
Animals
Chromosomes, Human, Pair 22
Disease Models, Animal
Genes, Neurofibromatosis 2
Genetic Testing
Humans
Immunohistochemistry
Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Neurofibromin 2

Neuroma, Acoustic

Promoter Regions, Genetic

RNA, Messenger

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 16436990
DOI: 10.1097/01.mao.0000180484.24242.54

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