Article
Stochastic theory of oncogenesis.
Anticancer research - 1 Jan 2000
Derkinderen D J, Boxma O J, Koten J W, Den Otter W
Abstract excerpt
It is generally agreed that most malignancies, particularly those that arise "spontaneously", are caused by randomly occurring mutations at specific sites of the genome. Hence oncogenesis of these spontaneous tumors can be described by stochastic mathematical models. In this paper we offer a mathematical approach to oncogenesis. A stochastic model was developed to calculate the number of mutations required for...
Topics
- Cell Transformation, Neoplastic
- Humans
- Models, Biological
- Mutation
- Neoplasms
- Oncogenes
- Statistics as Topic
- Stochastic Processes
- Suppression, Genetic