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Genetic Analysis of Intracranial Schwannomas: Differential NF2 Alteration Frequencies in Nonvestibular Schwannomas Versus Vestibular Schwannomas

15 May 2025

Abstract excerpt

BACKGROUND AND OBJECTIVES: Intracranial schwannomas are benign peripheral nerve sheath tumors usually identified as vestibular schwannomas (VSs). Among nonvestibular intracranial schwannomas (non-VSs), trigeminal and jugular foramen schwannomas are predominantly observed. Although the loss of NF2 function plays a significant role in sporadic VS tumorigenesis, a recent large-scale study showed the involvement of...

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PMID: 40372032
DOI: 10.1227/neu.0000000000003508

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