Article
The molecular genetics of vestibular schwannoma.
The Journal of laryngology and otology - 1 May 1995
Moffat D A, Irving R M
Abstract excerpt
Vestibular schwannoma occurs both as a sporadic tumour and in the dominantly inherited familial cancer syndrome neurofibromatosis type 2 (NF2). The gene for NF2 has recently been isolated on chromosome 22, and the demonstration of inactivating germline mutations in NF2 patients and NF2 associated tumours suggests that it acts as a tumour suppressor. The results of recent research in Cambridge suggest that somatic...
Topics
- Child
- Genes, Neurofibromatosis 2
- Genes, Retinoblastoma
- Genes, Tumor Suppressor
- Humans
- Models, Genetic
- Mutation
- Neuroma, Acoustic
- Proto-Oncogenes
- Vestibular Nerve