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Article

A four-hit mechanism is sufficient for meningioma development.

Journal of neuro-oncology - 1 Feb 2025

Devarajan Alex, Seah Carina, Zhang Jack Y, Vasan Vikram, Feng Rui, Chapman Emily K, Shigematsu Tomoyoshi, Bederson Joshua, Shrivastava Raj K

Abstract excerpt

PURPOSE: Meningiomas are central nervous system tumors whose incidence increases with age. Benign meningioma pathogenesis involves germline or somatic mutation of target genes, such as NF2, leading to clonal expansion. We used an established cancer epidemiology model to investigate the number of rate-limiting steps sufficient for benign meningioma development. METHODS: Incidence data was obtained from the...

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Identifiers

PMID: 39586894
DOI: 10.1007/s11060-024-04877-y

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NF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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