Article

An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2

2026-03-26

Abstract excerpt

Upstream open reading frames (uORFs) within the 5’-untranslated region (5’-UTR) of mRNA transcripts can regulate protein translation. Despite widespread prevalence within the human genome, they remain unidentified for many clinically relevant genes. A gene frequently associated with neonatal-onset epilepsy is KCNQ2 , which encodes a neuronal voltage-gated potassium channel subunit that functions to dampen neurona...

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Literature Corpus work: 1071ac0d-592c-5201-8a97-b5ccd71ef2bb
DOI: 10.64898/2026.03.24.713967

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