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Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders

6 Aug 2025

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA decay mechanism that serves the purpose of controlling both mRNA quality and quantity. As a quality control mechanism, NMD protects organisms against the deleterious effects of mRNAs that encode premature termination codons, which arise through either transcriptional errors or genetic variation. NMD is also employed as a major regulator of...

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PMID: 40774063
DOI: 10.1016/j.gde.2025.102394

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