Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2026

Huey Dalton J, Guadarrama Eduardo, DeKeyser Jean-Marc, Vanoye Carlos G, Simmons Christine Q, Li Qianru, Stroup Emily K, Ji Zhe, George Alfred L

Abstract excerpt

Upstream open reading frames (uORFs) within the 5'-untranslated region (5'-UTR) of messenger RNA transcripts can regulate protein translation. Despite widespread prevalence within the human genome, they remain unidentified for many clinically relevant genes. A gene frequently associated with neonatal-onset epilepsy is KCNQ2, which encodes a neuronal voltage-gated potassium channel subunit that functions to dampen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Codon, Initiator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to KCNQ2 Potassium Channel

Share to Mutation

Share to Neurons

Share to Open Reading Frames

Share to Protein Biosynthesis

Source

Open in PubMed Open full text

Identifiers

PMID: 42611988
DOI: 10.1073/pnas.2610782123
PMCID: PMC13506078

Genes

KCNQ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2.PMID 42611988Read ↗

An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2Semantic proximity Read ↗

Gene expression regulation by upstream open reading frames and human disease.Semantic proximity Read ↗

Disrupting upstream translation in mRNAs leads to loss-of-function associated with human diseaseSemantic proximity Read ↗

Disrupting upstream translation in mRNAs is associated with human disease.Semantic proximity Read ↗

Characterising the loss-of-function impact of 5’ untranslated region variants in whole genome sequence data from 15,708 individualsSemantic proximity Read ↗

Translation of numerous upstream open reading frames rather than their products is essential for proliferation of human cells of distinct originSemantic proximity Read ↗

Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals.Semantic proximity Read ↗

uORFdb--a comprehensive literature database on eukaryotic uORF biology.Semantic proximity Read ↗

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.Semantic proximity Read ↗

Translational effects and coding potential of an upstream open reading frame associated with DOPA Responsive Dystonia.Semantic proximity Read ↗

Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approachSemantic proximity Read ↗

Novel post-translational modification in voltage-gated potassium channel KCNQ2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.