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Genome, proteome, and immunome data explain why 6 month controlled human malaria infection with sporozoites of the Pf7G8 clone of <i>Plasmodium falciparum</i> is a rigorous predictor of the efficacy of the PfNF54-based PfSPZ Vaccine in Africa

2021-12-13

Abstract excerpt

<h4>ABSTRACT</h4> Controlled human malaria infection (CHMI) has supported Plasmodium falciparum (Pf) malaria vaccine development by providing preliminary estimates of vaccine efficacy (VE). Because CHMIs generally use Pf strains similar to vaccine strains, VE against antigenically heterogeneous Pf in the field has been required to establish VE. We increased the stringency of CHMI by selecting a Brazilian isolate,...

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Literature Corpus work
105a84d4-e7f5-5d26-8cfc-0fce86419d56
DOI
10.1101/2021.12.09.21266528
Open publication

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Genome, proteome, and immunome data explain why 6 month controlled human malaria infection with sporozoites of the Pf7G8 clone of <i>Plasmodium falciparum</i> is a rigorous predictor of the efficacy of the PfNF54-based PfSPZ Vaccine in AfricaDOI 10.1101/2021.12.09.21266528
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