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Article

Diversity and selection analyses identify transmission-blocking antigens as the optimal vaccine candidates in Plasmodium falciparum.

EBioMedicine - 1 Aug 2024

Ciubotariu Ilinca I, Broyles Bradley K, Xie Shaojun, Thimmapuram Jyothi, Mwenda Mulenga C, Mambwe Brenda, Mulube Conceptor, Matoba Japhet, Schue Jessica L, Moss William J, Bridges Daniel J, He Qixin, Carpi Giovanna

Abstract excerpt

BACKGROUND: A highly effective vaccine for malaria remains an elusive target, at least in part due to the under-appreciated natural parasite variation. This study aimed to investigate genetic and structural variation, and immune selection of leading malaria vaccine candidates across the Plasmodium falciparum's life cycle. METHODS: We analysed 325 P. falciparum whole genome sequences from Zambia, in addition to...

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Identifiers

PMID: 39018754
DOI: 10.1016/j.ebiom.2024.105227
PMCID: PMC11663769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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