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Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against<i>P. falciparum</i>clinical isolates

2024-05-24

Abstract excerpt

Vaccines to the Plasmodium falciparum reticulocyte binding-like protein homologue 5 (PfRH5) target the blood-stage of the parasite life cycle. PfRH5 has the potential to trigger the production of strain-transcendent antibodies and has proven its efficacy both in pre-clinical and early clinical studies. Vaccine-induced monoclonal antibodies (mAbs) to PfRH5 showed promising outcomes against cultured P. falciparum la...

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Literature Corpus work
02ecd27a-2d77-5186-a4aa-aa30616d8288
DOI
10.1101/2024.05.24.24305116
Open publication

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