Conserved genetic and antigenic profiles of Pf12 and Pf41 in asymptomatic Plasmodium falciparum carriers in Tanzania.

doi:10.1038/s41598-026-55360-9

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Article

Conserved genetic and antigenic profiles of Pf12 and Pf41 in asymptomatic Plasmodium falciparum carriers in Tanzania.

Scientific reports - 12 Jun 2026

Fitriana Fadhila, Lee Wang-Jong, Sim Hyun-Young, Jun Hojong, Syahada Jadidan Hada, Muh Fauzi, Lee Se Jin, Na Sunghun, Lee Kyu Joon, Nam Joo-Won, Han Eun-Taek, Todd Jim, Manjurano Alphaxard, Kidima Winifrida, Mazigo Ernest, Han Jin-Hee

Abstract excerpt

Plasmodium falciparum remains a major cause of mortality in malaria-endemic regions, and strain-specific immunity limits vaccine efficacy. The 6-cysteine proteins Pf12 and Pf41 are proposed blood-stage vaccine candidates, yet their diversity and antigenicity in asymptomatic carriers are poorly defined. Genetic variation and natural selection pressure were analyzed in 172 P. falciparum isolates from asymptomatic...

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Identifiers

PMID: 42286103
DOI: 10.1038/s41598-026-55360-9
PMCID: PMC13507067

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