Article
RTS,S/AS01 malaria vaccine mismatch observed among Plasmodium falciparum isolates from southern and central Africa and globally.
Scientific reports - 26 Apr 2018
Pringle Julia C, Carpi Giovanna, Almagro-Garcia Jacob, Zhu Sha Joe, Kobayashi Tamaki, Mulenga Modest, Bobanga Thierry, Chaponda Mike, Moss William J, Norris Douglas E
Abstract excerpt
The RTS,S/AS01 malaria vaccine encompasses the central repeats and C-terminal of Plasmodium falciparum circumsporozoite protein (PfCSP). Although no Phase II clinical trial studies observed evidence of strain-specific immunity, recent studies show a decrease in vaccine efficacy against non-vaccine strain parasites. In light of goals to reduce malaria morbidity, anticipating the effectiveness of RTS,S/AS01 is...
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