Article

Genetic Diversity of Plasmodium falciparum (Pf) Field Isolates for the Development of Novel Controlled Human Malaria Infection (CHMI) Challenge Strains

2026-05-08

Abstract excerpt

<title>Abstract</title> Genetic diversity in Plasmodium falciparum (Pf) antigens complicates malaria vaccine design and efficacy testing in controlled human malaria infection (CHMI) studies. Existing CHMI strains capture limited global diversity, restricting evaluation of vaccines. We analyzed clinical isolates from Ghana, Kenya, Thailand, and Colombia. Monoclonal infections were genotyped at 12 neutral micros...

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Literature Corpus work: 3ed67d4d-11a2-5e3e-8e9c-f6c511474774
DOI: 10.21203/rs.3.rs-9314776/v1

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