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Article

Strains used in whole organism <i>Plasmodium falciparum</i> vaccine trials differ in genome structure, sequence, and immunogenic potential

2019-06-27

Abstract excerpt

<h4>Background</h4> Plasmodium falciparum (Pf) whole-organism sporozoite vaccines have provided excellent protection against controlled human malaria infection (CHMI) and naturally transmitted heterogeneous Pf in the field. Initial CHMI studies showed significantly higher durable protection against homologous than heterologous strains, suggesting the presence of strain-specific vaccine-induced protection. However...

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Literature Corpus work
d32e1c87-3926-56a5-8f28-9a37d8b4cc88
DOI
10.1101/684175
Open publication

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