Article

Cryo-EM of PMEL Amyloids Reveals Pathogenic Mechanism of Pigment Dispersion Syndrome.

2024-12-11

Abstract excerpt

<title>Abstract</title> <p>PMEL amyloids provide a vital scaffold for melanin deposition in melanosomes, playing a central role in pigmentation. Despite their importance, the high-resolution structure of PMEL amyloids has remained elusive. Here, we determined near-atomic resolution structures of wild-type PMEL amyloids using cryo-electron microscopy, revealing two distinct polymorphic forms with unique structural...

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Literature Corpus work: 102ad2ae-4c95-5ba5-aff4-1b5b5f59dc5e
DOI: 10.21203/rs.3.rs-5540188/v1

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