Article

Cryo-EM of PMEL Amyloids Reveals Pathogenic Mechanism of Pigment Dispersion Syndrome

2024-12-12

Abstract excerpt

PMEL amyloids provide a vital scaffold for melanin deposition in melanosomes, playing a central role in pigmentation. Despite their importance, the high-resolution structure of PMEL amyloids has remained elusive. Here, we determined near-atomic resolution structures of wild-type PMEL amyloids using cryo-electron microscopy, revealing two distinct polymorphic forms with unique structural features. We further examin...

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Literature Corpus work: 3e91c0ca-4764-5da1-8d55-11ab7d640f1f
DOI: 10.1101/2024.12.09.627633

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