Article
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores.
Nature structural & molecular biology - 1 Sept 2021
Cao Qin, Boyer David R, Sawaya Michael R, Abskharon Romany, Saelices Lorena, Nguyen Binh A, Lu Jiahui, Murray Kevin A, Kandeel Fouad, Eisenberg David S
Abstract excerpt
Amyloidosis of human islet amyloid polypeptide (hIAPP) is a pathological hallmark of type II diabetes (T2D), an epidemic afflicting nearly 10% of the world's population. To visualize disease-relevant hIAPP fibrils, we extracted amyloid fibrils from islet cells of a T2D donor and amplified their quantity by seeding synthetic hIAPP. Cryo-EM studies revealed four fibril polymorphic atomic structures. Their...
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