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Article

Programmed mitophagy at the oocyte-to-zygote transition promotes lineage endurance.

Nature cell biology - 1 Feb 2026

Thendral Siddharthan B, Bacot Sasha, Ryde Ian T, Morton Katherine S, Chi Qiuyi, Kenny-Ganzert Isabel W, Meyer Joel N, Sherwood David R

Abstract excerpt

The quality of mitochondria inherited from the oocyte determines embryonic viability, lifelong metabolic health of the progeny and lineage endurance. High levels of endogenous reactive oxygen species and exogenous toxicants pose threats to mitochondrial DNA (mtDNA) in fully developed oocytes. Deleterious mtDNA is commonly detected in mature oocytes, but is absent in embryos, suggesting the existence of a cryptic...

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Identifiers

PMID: 41526527
DOI: 10.1038/s41556-025-01854-z
PMCID: PMC12918445

Genes

BNIP3
FUNDC1
PINK1

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