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Article

Two genomes, one destiny: Mitophagy at the crossroads of inheritance and disease.

Cell chemical biology - 18 Dec 2025

Chung Chih-Yao, Singh Kritarth, Pinho Brigida R, Oliveira Jorge M A, Duchen Michael R

Abstract excerpt

Mechanisms ensuring mito-nuclear compatibility are poorly understood. In a recent study published in Science,1 Frison et al. found that a mouse mitochondrial DNA (mtDNA) mutation can escape mitochondrial surveillance in embryogenesis by repressing the ubiquitin-proteasome system. Inhibition of USP30 restored ubiquitin-mediated mitophagy and reduced mutant burden, suggesting a potential therapeutic target for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41418762
DOI: 10.1016/j.chembiol.2025.11.010

Genes

USP30

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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