Article

Loss of CD109 Amplifies NF-κB Signaling and Inflammatory Reprogramming in Dermal Fibroblasts

2026-07-06

Abstract excerpt

Fibroproliferative diseases such as systemic sclerosis are complex conditions characterized by chronic skin inflammation and progressive fibrosis, with fibroblast activation as a central feature. While Transforming Growth Factor Beta (TGF-β) signaling is a well-established driver of fibrosis in SSc, inflammatory pathways such as Nuclear Factor Kappa B (NF-κB) also contribute substantially to disease morbidity. We...

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Literature Corpus work: 0fe236ed-f477-5161-b258-52920cf383d4
DOI: 10.64898/2026.07.03.736423

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