Article

Cutaneous lupus features specialized stromal niches and altered retroelement expression

2025-02-06

Abstract excerpt

Cutaneous Lupus is an inflammatory skin disease causing highly morbid inflamed skin and hair loss. In order to investigate the pathophysiology of cutaneous lupus, we performed single-cell RNA and spatial sequencing of lesional and non-lesional cutaneous lupus skin compared to healthy controls. Pathway enrichment analyses of lesional keratinocytes revealed elevated responses to type I interferon, type II interferon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b038fc90-1fc9-5fb3-9e81-bcc53b68300e
DOI: 10.1101/2025.02.01.636053

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cutaneous lupus features specialized stromal niches and altered retroelement expressionDOI 10.1101/2025.02.01.636053Read

Cutaneous Lupus Features Specialized Stromal Niches and Altered Retroelement ExpressionSemantic proximity Read

Transcriptomic analysis reveals immune signatures associated with specific cutaneous manifestations of lupus in systemic lupus erythematosusSemantic proximity Read

Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosusSemantic proximity Read

Single cell transcriptomics reveals distinct effector profiles of infiltrating T cells in lupus skin and kidneySemantic proximity Read

Non-lesional and Lesional Lupus Skin Share Inflammatory Phenotypes that Drive Activation of CD16+ Dendritic CellsSemantic proximity Read

Molecular Profiling of Cutaneous Lupus Lesions Identifies Subgroups Distinct from Clinical PhenotypesSemantic proximity Read

Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous LupusSemantic proximity Read

Lupus dermal fibroblasts are proinflammatory and exhibit a profibrotic phenotype in scarring skin disease.Semantic proximity Read

Recent insights into the role of innate immunity in lupusSemantic proximity Read

KLHDC7B as a Potential Therapeutic Target in Systemic Lupus Erythematosus: Insights from Bulk and Single-Cell RNA-Seq and Spatial Transcriptomics of Epidermal KeratinocytesSemantic proximity Read

From Genes to Pathways: The Molecular Landscape of Systemic Lupus Erythematosus.Semantic proximity Read

A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9 <sup>+</sup> Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive AutoimmunitySemantic proximity Read