Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis

Abstract excerpt

Abstract The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A and TNF inflammatory responses in the absence of neutrophil proteases, which primarily occur within the supraspinous layer of the psoriatic epidermis. We further show...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Dermatology and Skin Diseases
• Share to Psoriasis: Treatment and Pathogenesis
• Share to T-cell and B-cell Immunology