Article
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.
The Lancet. Respiratory medicine - 1 Nov 2017
Allen Richard J, Porte Joanne, Braybrooke Rebecca, Flores Carlos, Fingerlin Tasha E, Oldham Justin M, Guillen-Guio Beatriz, Ma Shwu-Fan, Okamoto Tsukasa, John Alison E, Obeidat Ma'en, Yang Ivana V, Henry Amanda, Hubbard Richard B, Navaratnam Vidya, Saini Gauri, Thompson Norma, Booth Helen L, Hart Simon P, Hill Mike R, Hirani Nik, Maher Toby M, McAnulty Robin J, Millar Ann B, Molyneaux Philip L, Parfrey Helen, Rassl Doris M, Whyte Moira K B, Fahy William A, Marshall Richard P, Oballa Eunice, Bossé Yohan, Nickle David C, Sin Don D, Timens Wim, Shrine Nick, Sayers Ian, Hall Ian P, Noth Imre, Schwartz David A, Tobin Martin D, Wain Louise V, Jenkins R Gisli
Abstract excerpt
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncertain cause, and few treatment options. Studies have identified a significant genetic risk associated with the development of IPF; however, mechanisms by which genetic risk factors promote IPF remain unclear. We aimed to identify genetic variants associated with IPF susceptibility and provide mechanistic...
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