Article

Multiple system atrophy is associated with brain somatic mutations in clonal hematopoiesis genes

2026-03-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Multiple system atrophy (MSA) is a sporadic disorder characterized by alpha-synuclein inclusions. Somatic mutations may contribute to neurodegeneration, with somatic copy number variants in SNCA (alpha-synuclein) reported in MSA, and somatic mutations in cancer driver genes in Alzheimer’s disease. <h4>Objectives</h4> To investigate whether small somatic mutations (single...

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Literature Corpus work: 0fa2cf27-f895-577e-bc51-9075db7f08cd
DOI: 10.64898/2026.03.17.26346081

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